EntityQ282003· pop 36· linked from 738 articles

lindane

Lindane, also known as '''gamma-hexachlorocyclohexane (γ-HCH), gammaxene, Gammallin and benzene hexachloride (BHC'''), is an organochlorine chemical and an isomer of hexachlorocyclohexane that has been used both as an agricultural insecticide and as a pharmaceutical treatment for lice and scabies.

Key facts

Drug.verifiedrevid: 457117932
Drug.IUPAC_name: (1r,2R,3S,4r,5R,6S)-1,2,3,4,5,6-hexachlorocyclohexane
Drug.image: Gamma-hexachlorocyclohexane.svg
Drug.image_class: skin-invert-image
Drug.width: 150px
Drug.image2: Lindane (chair) molecule ball.png
Drug.image_class2: bg-transparent
Drug.width2: 170
Drug.alt2: Ball-and-stick model of the lindane molecule (chair conformation)
Drug.MedlinePlus: a682651
Drug.pregnancy_category: C
Drug.legal_status: Production and agricultural use is banned in the 182 countries that are Parties to the Stockholm Convention, but pharmaceutical use is allowed as a second-line treatment for scabies and lice
Drug.routes_of_administration: Topical
Drug.protein_bound: 91%
Drug.metabolism: Hepatic cytochrome P-450 oxygenase system
Drug.elimination_half life: 18 hours
Drug.CAS_number: 58-89-9
Drug.ATC_prefix: P03

via Wikipedia infobox

Article

16 sections

Contents

History and use
United States
Pharmaceutical uses
Other uses
Pest repellent
Synthesis
Human health effects
Cancer risk
Adverse reactions
Environmental contamination
Isomers
See also
References
External links
Government and organizations
News stories and opinion articles

Lindane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABAA receptor-chloride channel complex at the picrotoxin binding site. In humans, lindane affects the nervous system, liver, and kidneys, and may well be a carcinogen. Whether lindane is an endocrine disruptor is unclear.