لومیتاپید

Also known as AEGR-733, BMS-201038, Juxtapid®, Lojuxta®, BMS 201038, AEGR 733, Lomitapide

Lomitapide , sold under the brand name Juxtapid in the US and Lojuxta in the EU, is a medication used as a lipid-lowering agent for the treatment of familial hypercholesterolemia, developed by Aegerion Pharmaceuticals. It has been tested in clinical trials as single treatment and in combinations with atorvastatin, ezetimibe and fenofibrate.

Chemical data

Formula: C39H37F6N3O2
Molecular weight: 693.7 g/mol
IUPAC name: N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide
SMILES: C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F
InChIKey: MBBCVAKAJPKAKM-UHFFFAOYSA-N
XLogP: 8.6
Polar surface area: 61.4 Å²
H-bond donors: 2
H-bond acceptors: 9
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 2012
Admin. routes: oral
Indications: cardiovascular disease, familial hypercholesterolemia, homozygous familial hypercholesterolemia

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 693.279
Has use: medication

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medical condition treated: lipedema
chemical formula: C₃₉H₃₇F₆N₃O₂
canonical SMILES: C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F
World Health Organisation international non-proprietary name: lomitapide
defined daily dose: 40
Commons category: Lomitapide
physically interacts with: Microsomal triglyceride transfer protein
significant drug interaction: itraconazole

Sources (5)

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