lurtotecan
Sign in to saveLurtotecan is a semi-synthetic analog of camptothecin with antineoplastic activity. Liposomal lurtotecan was in clinical trials as a treatment for topotecan-resistant ovarian cancer, but was discontinued.
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 518.217
- Has use
- medication
Show 5 more facts
- chemical formula
- C₂₈H₃₀N₄O₆
- canonical SMILES
- CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC6=C(C=C5N=C4C3=C2)OCCO6)CN7CCN(CC7)C)O
- isomeric SMILES
- CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC6=C(C=C5N=C4C3=C2)OCCO6)CN7CCN(CC7)C)O
- subject has role
- antineoplastic
- Commons category
- Lurtotecan
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Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Lurtotecan is a semi-synthetic analog of camptothecin with antineoplastic activity. Liposomal lurtotecan was in clinical trials as a treatment for topotecan-resistant ovarian cancer, but was discontinued.
==Synthesis== thumb|center|600px|class=skin-invert-image|Lurtotecan synthesis Heck reaction Mitsunobu reaction Potassium osmate Sharpless asymmetric dihydroxylation Swern oxidation
Excerpted from Wikipedia’s “lurtotecan” article, available under the CC BY-SA 4.0 licence.