mycofenolzuur
Also known as ERL080, ERL-080, (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
chemische verbinding
Chemical data
- Formula
- C17H20O6
- Molecular weight
- 320.3 g/mol
- IUPAC name
- (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
- SMILES
- CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\C)/CCC(=O)O)O
- InChIKey
- HPNSFSBZBAHARI-RUDMXATFSA-N
- XLogP
- 3.2
- Polar surface area
- 93.1 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
10,995 papersArticle · Nederlands
Mycofenolzuur (mycophenolic acid, MPA) is de werkzame stof van de geneesmiddelen Mycofenolaatmofetil (MMF, CellCept van Roche) en Mycofenolzuur natrium (EC-MPS, entric coated mycophenolic acid sodium, Myfortic van Novartis. Het geneesmiddel is een immunosuppressivum. Het middel remt het enzym IMPDH, waardoor het afweersysteem zwakker wordt. In combinatie met andere immunosuppresiva wordt het profylactisch toegepast tegen afstotingsreacties van getransplanteerde organen.
Abstract from DBpedia / Wikipedia · CC BY-SA
Connections
Categories
Carboxylic acidsChemicals using indexlabelsDrugboxes which contain changes to verified fieldsDrugboxes which contain changes to watched fieldsDrugs developed by GenentechDrugs developed by Hoffmann-La RocheDrugs developed by NovartisDrugs with non-standard legal statusECHA InfoCard ID from WikidataHydroxyarenesImmunosuppressantsInfobox drug with local INN variant