N,N-dimethylacetamide
Dimethylacetamide (DMAc or DMA) is the organic compound with the formula CH3C(O)N(CH3)2. This colorless, water-miscible, high-boiling liquid is commonly used as a polar solvent in organic synthesis. DMA is miscible with most other solvents, although it is poorly soluble in aliphatic hydrocarbons.
Research
1,045 papers- Health risks of N,N-dimethylacetamide (DMAC) in humans.Journal of occupational health · 2025
- Recent Uses of N,N-Dimethylformamide and N,N-Dimethylacetamide as Reagents.Molecules (Basel, Switzerland) · 2018
- Repurposing N,N-Dimethylacetamide (DMA), a Pharmaceutical Excipient, as a Prototype Novel Anti-inflammatory Agent for the Prevention and/or Treatment of Preterm Birth.Current pharmaceutical design · 2018
- N,N-dimethylacetamide targets neuroinflammation in Alzheimer's disease in in-vitro and ex-vivo models.Scientific reports · 2023
- A Journey from June 2018 to October 2021 with N,N-Dimethylformamide and N,N-Dimethylacetamide as Reactants.Molecules (Basel, Switzerland) · 2021
via PubMed
Article
7 sectionsContents
- Synthesis and production
- Reactions and applications
- Toxicity
- Regulation
- See also
- References
- External links
Dimethylacetamide (DMAc or DMA) is the organic compound with the formula CH3C(O)N(CH3)2. This colorless, water-miscible, high-boiling liquid is commonly used as a polar solvent in organic synthesis. DMA is miscible with most other solvents, although it is poorly soluble in aliphatic hydrocarbons.
==Synthesis and production== DMA is prepared commercially by the reaction of dimethylamine with acetic anhydride or acetic acid. Dehydration of the salt of dimethylamine and acetic acid also furnishes this compound: CH3CO2H·HN(CH3)2 → H2O + CH3CON(CH3)2