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N,N-dimethylacetamide
Sign in to saveAlso known as Dimethyl acetamide, N,N-Dimethyl acetamide, DMAC, dimethylacetamide
Dimethylacetamide (DMAc or DMA) is the organic compound with the formula CH3C(O)N(CH3)2. This colorless, water-miscible, high-boiling liquid is commonly used as a polar solvent in organic synthesis. DMA is miscible with most other solvents, although it is poorly soluble in aliphatic hydrocarbons.
In the Vinony graph
Vinony's link graph records 56 inbound references to N,N-dimethylacetamide, and connects out to Quebec, medication and International Standard Book Number.
It is catalogued under topics including Acetamides, Amide solvents and Chembox having GHS data.
Vinony links it to 23 Wikipedia language editions.
Chemical data
- Formula
- C4H9NO
- Molecular weight
- 87.12 g/mol
- IUPAC name
- N,N-dimethylacetamide
- SMILES
- CC(=O)N(C)C
- InChIKey
- FXHOOIRPVKKKFG-UHFFFAOYSA-N
- XLogP
- -0.8
- Polar surface area
- 20.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
1,045 papers- Health risks of N,N-dimethylacetamide (DMAC) in humans.Journal of occupational health · 2025
- Recent Uses of N,N-Dimethylformamide and N,N-Dimethylacetamide as Reagents.Molecules (Basel, Switzerland) · 2018
- Repurposing N,N-Dimethylacetamide (DMA), a Pharmaceutical Excipient, as a Prototype Novel Anti-inflammatory Agent for the Prevention and/or Treatment of Preterm Birth.Current pharmaceutical design · 2018
- N,N-dimethylacetamide targets neuroinflammation in Alzheimer's disease in in-vitro and ex-vivo models.Scientific reports · 2023
- A Journey from June 2018 to October 2021 with N,N-Dimethylformamide and N,N-Dimethylacetamide as Reactants.Molecules (Basel, Switzerland) · 2021
via PubMed
Wikidata facts
- Subclass of
- carboxamides
- Has part
- carbon
- Mass
- 87.068
- Image
- DMA (extra dry).jpg
Show 15 more facts
- melting point
- -20.0
- chemical formula
- C₄H₉NO
- canonical SMILES
- CC(=O)N(C)C
- immediately dangerous to life or health
- 1068
- NIOSH Pocket Guide ID
- 0218
- density
- 0.94
- boiling point
- 165
- vapor pressure
- 2
- flash point
- 158
- lower flammable limit
- 1.8
- upper flammable limit
- 11.5
- ionization energy
- 8.81
- safety classification and labelling
- Regulation (EC) No. 1272/2008
- time-weighted average exposure limit
- 35
- Commons category
- Dimethylacetamide
via Wikidata · CC0
~4 min read
Encyclopedic overview
7 sectionsContents
- Synthesis and production
- Reactions and applications
- Toxicity
- Regulation
- See also
- References
- External links
Dimethylacetamide (DMAc or DMA) is the organic compound with the formula CH3C(O)N(CH3)2. This colorless, water-miscible, high-boiling liquid is commonly used as a polar solvent in organic synthesis. DMA is miscible with most other solvents, although it is poorly soluble in aliphatic hydrocarbons.
==Synthesis and production== DMA is prepared commercially by the reaction of dimethylamine with acetic anhydride or acetic acid. Dehydration of the salt of dimethylamine and acetic acid also furnishes this compound: CH3CO2H·HN(CH3)2 → H2O + CH3CON(CH3)2
Excerpted from Wikipedia’s “N,N-dimethylacetamide” article, available under the CC BY-SA 4.0 licence.