Structure via PubChem · Public domain (PubChem)
niaprazine
Sign in to saveNiaprazine (INN; brand name Nopron) is a sedative-hypnotic drug of the phenylpiperazine group. It has been used in the treatment of sleep disturbances since the early 1970s in several European countries including France, Italy, and Luxembourg. It is commonly used with children and adolescents on account of its favorable safety and tolerability profile and lack of abuse potential.
Chemical data
- Formula
- C20H25FN4O
- Molecular weight
- 356.4 g/mol
- IUPAC name
- N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide
- SMILES
- CC(CCN1CCN(CC1)C2=CC=C(C=C2)F)NC(=O)C3=CN=CC=C3
- InChIKey
- RSKQGBFMNPDPLR-UHFFFAOYSA-N
- XLogP
- 2.6
- Polar surface area
- 48.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 356.20124
Show 3 more facts
- Commons category
- Niaprazine
- canonical SMILES
- CC(CCN1CCN(CC1)C2=CC=C(C=C2)F)NC(=O)C3=CN=CC=C3
- chemical formula
- C₂₀H₂₅FN₄O
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
{{Drugbox | IUPAC_name = N-{4-[4-(4-fluorophenyl)piperazin- 1-yl]butan- 2-yl}pyridine- 3-carboxamide | image = Niaprazine.svg | image_class = skin-invert-image | width = 250px
| tradename = Nopron | Drugs.com = | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Oral | class = Serotonin 5-HT2A receptor antagonist; α1-Adrenergic receptor antagonist
Excerpted from Wikipedia’s “niaprazine” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
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