NIFK

Also known as MKI67IP, Nopp34, nucleolar protein interacting with the FHA domain of MKI67

MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene.

Gene data

NIFK

Name: nucleolar protein interacting with the FHA domain of MKI67
Type: protein-coding
Aliases: MKI67IP, Nop15, Nopp34

This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009].

via MyGene.info

Gene · Ensembl

nucleolar protein interacting with the FHA domain of MKI67

Symbol: NIFK
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:121,724,715-121,737,120
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein MKI67IP PDB 2aff.png

Show 5 more facts

HomoloGene ID: 49862
exact match: identifiers.org/ncbigene/84365
genomic end: 121736911
genomic start: 122484521
cytogenetic location: 2q14.3

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MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene.

MKI67 FHA domain-interacting nucleolar phosphoprotein contains an RNA recognition motif (RRM) near to the N-terminus and a FHA Ki67 binding domain near to the C-terminus. There are two conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this domain binds to the forkhead-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation.