NIFK
Sign in to saveAlso known as MKI67IP, Nopp34, nucleolar protein interacting with the FHA domain of MKI67
MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene.
Gene data
NIFK- Name
- nucleolar protein interacting with the FHA domain of MKI67
- Type
- protein-coding
- Position
- 121,724,715–121,737,120 (−)
- Aliases
- MKI67IP, Nop15, Nopp34
- Ensembl
- ENSG00000155438
- RefSeq RNA
- NM_032390.5
- RefSeq protein
- NP_115766.3
This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009].
Gene Ontology
via MyGene.info
Gene · Ensembl
nucleolar protein interacting with the FHA domain of MKI67
- Symbol
- NIFK
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:121,724,715-121,737,120
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene.
MKI67 FHA domain-interacting nucleolar phosphoprotein contains an RNA recognition motif (RRM) near to the N-terminus and a FHA Ki67 binding domain near to the C-terminus. There are two conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this domain binds to the forkhead-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation.
Excerpted from Wikipedia’s “NIFK” article, available under the CC BY-SA 4.0 licence.