Structure via PubChem · Public domain (PubChem)
niludipine
Sign in to saveNiludipine is a calcium channel blocker of the dihydropyridine class. It is a vasodilator that acts upon the coronary arteries of the heart-lung. It was found to produce a calcium antagonistic effect on the smooth muscle of hearts of canines and guinea pigs inhibiting myocardial oxidative metabolism.
Chemical data
- Formula
- C25H34N2O8
- Molecular weight
- 490.5 g/mol
- IUPAC name
- bis(2-propoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- SMILES
- CCCOCCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOCCC)C)C
- InChIKey
- VZWXXKDFACOXNT-UHFFFAOYSA-N
- XLogP
- 3.9
- Polar surface area
- 129 Ų
- H-bond donors
- 1
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
44 papers- Effects of Ca antagonists, nifedipine, niludipine and verapamil, on endocrine function of the pancreas.The Tohoku journal of experimental medicine · 1983
- Treatment of angina pectoris patients with niludipine a new calcium antagonistic drug.Arzneimittel-Forschung · 1981
- Antihypertensive effect of Niludipine (Bay a 7168) on conscious renal-hypertensive dogs.Arzneimittel-Forschung · 1979
- Acute hypotensive, hemodynamic effects of long-term treatment with niludipine, a Ca2+-antagonist, in patients with essential hypertension. Niludipine monotherapy and combination with a beta-blocker and a diuretic).Arzneimittel-Forschung · 1982
- Protection of the ischemic myocardium with calcium antagonistic drugs.Arzneimittel-Forschung · 1983
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 490.231516
Show 4 more facts
- canonical SMILES
- CCCOCCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOCCC)C)C
- chemical formula
- C₂₅H₃₄N₂O₈
- subject has role
- calcium channel blocker
- Commons category
- Niludipine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Niludipine is a calcium channel blocker of the dihydropyridine class. It is a vasodilator that acts upon the coronary arteries of the heart-lung. It was found to produce a calcium antagonistic effect on the smooth muscle of hearts of canines and guinea pigs inhibiting myocardial oxidative metabolism.
==References==
Excerpted from Wikipedia’s “niludipine” article, available under the CC BY-SA 4.0 licence.