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niludipine

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Niludipine is a calcium channel blocker of the dihydropyridine class. It is a vasodilator that acts upon the coronary arteries of the heart-lung. It was found to produce a calcium antagonistic effect on the smooth muscle of hearts of canines and guinea pigs inhibiting myocardial oxidative metabolism.

Research

44 papers

Effects of Ca antagonists, nifedipine, niludipine and verapamil, on endocrine function of the pancreas.The Tohoku journal of experimental medicine · 1983
Treatment of angina pectoris patients with niludipine a new calcium antagonistic drug.Arzneimittel-Forschung · 1981
Antihypertensive effect of Niludipine (Bay a 7168) on conscious renal-hypertensive dogs.Arzneimittel-Forschung · 1979
Acute hypotensive, hemodynamic effects of long-term treatment with niludipine, a Ca2+-antagonist, in patients with essential hypertension. Niludipine monotherapy and combination with a beta-blocker and a diuretic).Arzneimittel-Forschung · 1982
Protection of the ischemic myocardium with calcium antagonistic drugs.Arzneimittel-Forschung · 1983

Wikidata facts

Mass: 490.231516

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canonical SMILES: CCCOCCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOCCC)C)C
chemical formula: C₂₅H₃₄N₂O₈
Commons category: Niludipine

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Niludipine is a calcium channel blocker of the dihydropyridine class. It is a vasodilator that acts upon the coronary arteries of the heart-lung. It was found to produce a calcium antagonistic effect on the smooth muscle of hearts of canines and guinea pigs inhibiting myocardial oxidative metabolism.

==References==

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Categories

3-Nitrophenyl compounds Calcium channel blockers Carboxylate esters Chembox image size set ECHA InfoCard ID from Wikidata Ethers Propoxy compounds Pyridines