ニムスチン

Chemical data

Formula

C9H13ClN6O2

Molecular weight

272.69 g/mol

IUPAC name

3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-nitrosourea

SMILES

CC1=NC=C(C(=N1)N)CNC(=O)N(CCCl)N=O

InChIKey

VFEDRRNHLBGPNN-UHFFFAOYSA-N

XLogP

0.4

Polar surface area

114 Ų

H-bond donors

2

H-bond acceptors

6

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Phase 2

Molecule type

Small molecule

Indications

neoplasm, glioblastoma multiforme

via ChEMBL · EBI

• Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma.Open veterinary journal · 2024
• Nimustine Treatment of 11 Cases of Canine Histiocytic Sarcoma.Journal of the American Animal Hospital Association · 2020
• Retrospective evaluation of nimustine use in the treatment of feline lymphoma.Veterinary medicine and science · 2022
• Local Delivery of Nimustine Hydrochloride against Brain Tumors: Basic Characterization Study.The Tohoku journal of experimental medicine · 2023
• Regression of Recurrent Spinal Cord High-Grade Glioma After Convection-Enhanced Delivery of Nimustine Hydrochloride: Case Reports and Literature Review.Operative neurosurgery (Hagerstown, Md.) · 2020

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

272.078851

Has use

medication

via Wikidata · CC0