NPY1R
Sign in to saveAlso known as NPY1-R, NPYR, Neuropeptide Y receptor Y1
protein-coding gene in the species Homo sapiens
Gene data
NPY1R- Name
- neuropeptide Y receptor Y1
- Type
- protein-coding
- Position
- 163,323,962–163,344,852 (−)
- Aliases
- NPY1-R, NPYR
- Ensembl
- ENSG00000164128
- RefSeq RNA
- NM_000909.6, XM_005263031.5, XM_011532010.4, XM_054350119.1, XM_054350120.1
- RefSeq protein
- NP_000900.1, XP_005263088.1, XP_011530312.1, XP_054206094.1, XP_054206095.1
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013].
Gene Ontology
Biological process
outflow tract morphogenesiscell communicationG protein-coupled receptor signaling pathwayG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayadenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayneuropeptide signaling pathwaysignaling
Molecular function
Pathways
cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Regulation of lipolysis in adipocytes - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)Peptide ligand-binding receptorsGPCR downstream signallingG alpha (i) signalling eventsGPCR ligand binding
via MyGene.info
Gene · Ensembl
neuropeptide Y receptor Y1
- Symbol
- NPY1R
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:163,323,085-163,344,852
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein NPY1R PDB 2F1U.png
Show 5 more facts
- HomoloGene ID
- 700
- genomic end
- 164265984
- exact match
- identifiers.org/ncbigene/4886
- genomic start
- 163323962
- cytogenetic location
- 4q32.2
Sources (3)
via Wikidata · CC0
Connections
Q180686
Entity
Ensembl genome database project
Entity
cell surface receptor
Entity
protein
Entity
Wikidata
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gene
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chromosome
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digital object identifier
Entity
pheromone
Entity
bibcode
Entity
human genome
Entity
Q229883
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base pair
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locus
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gene expression
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Online Mendelian Inheritance in Man
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G protein-coupled recepteishon
Entity
Protein Data Bank
Entity
rhodopsin
Protein
Q22908627
Entity