اوئنانتوتوکسین

Also known as enanthotoxin, (2E,8E,10E,14R)-2,8,10-heptadecatriene-4,6-diyne-1,14-diol, (+)-enanthotoxin, (+)-oenanthotoxin, (R)-enanthotoxin, (R)-oenanthotoxin

Oenanthotoxin is a toxin extracted from hemlock water-dropwort (Oenanthe crocata) and other plants of the genus Oenanthe. It is a central nervous system poison, and acts as a noncompetitive antagonist of the neurotransmitter gamma-aminobutyric acid. A case has been made for the presence of this toxin in local Oenanthe species playing a causative role in euthanasia in ancient Sardinia. It was crystallized in 1949 by Clarke and co-workers. It is structurally closely related to the toxins cicutoxin and carotatoxin. Oenanthotoxin is a C17 polyacetylene isomer of cicutoxin.