OSBPL8
Sign in to saveAlso known as MST120, MSTP120, ORP8, OSBP10, oxysterol binding protein like 8
Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.
Gene data
OSBPL8- Name
- oxysterol binding protein like 8
- Type
- protein-coding
- Position
- 76,351,797–76,559,809 (−)
- Aliases
- MST120, MSTP120, ORP8, OSBP10
- Ensembl
- ENSG00000091039
- RefSeq RNA
- NM_001003712.2, NM_001319652.2, NM_001319653.2, NM_001319655.2, NM_020841.5
- RefSeq protein
- NP_001003712.1, NP_001306581.1, NP_001306582.1, NP_001306584.1, NP_065892.1
This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
oxysterol binding protein like 8
- Symbol
- OSBPL8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:76,351,319-76,559,840
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein OSBPL8 PDB 1v88.png
Show 5 more facts
- HomoloGene ID
- 68813
- exact match
- identifiers.org/ncbigene/114882
- genomic start
- 76745577
- genomic end
- 76953589
- cytogenetic location
- 12q21.2
Sources (3)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intravenous lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.