OSBPL8

Also known as MST120, MSTP120, ORP8, OSBP10, oxysterol binding protein like 8

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.

Gene data

OSBPL8

Name: oxysterol binding protein like 8
Type: protein-coding
Position: 76,351,797–76,559,809 (−)
Aliases: MST120, MSTP120, ORP8, OSBP10
Ensembl: ENSG00000091039
RefSeq RNA: NM_001003712.2, NM_001319652.2, NM_001319653.2, NM_001319655.2, NM_020841.5
RefSeq protein: NP_001003712.1, NP_001306581.1, NP_001306582.1, NP_001306584.1, NP_065892.1

This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

Pathways

Metabolism Acyl chain remodelling of PS Glycerophospholipid biosynthesis Phospholipid metabolism Metabolism of lipids

via MyGene.info

Wikidata facts

Image: Protein OSBPL8 PDB 1v88.png

Show 5 more facts

HomoloGene ID: 68813
exact match: identifiers.org/ncbigene/114882
genomic start: 76745577
genomic end: 76953589
cytogenetic location: 12q21.2

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Further reading

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intravenous lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.