OSBPL8

Also known as MST120, MSTP120, ORP8, OSBP10, oxysterol binding protein like 8

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.

In the Vinony graph

Vinony's link graph records 3 inbound references to OSBPL8, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 12.

Vinony links it to 6 Wikipedia language editions.

Gene data

OSBPL8

Name: oxysterol binding protein like 8
Type: protein-coding
Position: 76,351,319–76,559,840 (−)
Aliases: MST120, MSTP120, ORP8, OSBP10
Ensembl: ENSG00000091039
RefSeq RNA: NM_001003712.2, NM_001319652.2, NM_001319653.2, NM_001319655.2, NM_020841.5
RefSeq protein: NP_001003712.1, NP_001306581.1, NP_001306582.1, NP_001306584.1, NP_065892.1

This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

Pathways

Metabolism Acyl chain remodelling of PS Glycerophospholipid biosynthesis Phospholipid metabolism Metabolism of lipids

via MyGene.info

Gene · Ensembl

oxysterol binding protein like 8

Symbol: OSBPL8
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:76,351,319-76,559,840
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein OSBPL8 PDB 1v88.png

Show 8 more facts

HomoloGene ID: 68813
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/114882
genomic start: 76745577
chromosome: human chromosome 12
genomic end: 76953589
cytogenetic location: 12q21.2
expressed in: superficial temporal artery

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intravenous lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.

Excerpted from Wikipedia’s “OSBPL8” article, available under the CC BY-SA 4.0 licence.