OSBPL2

Also known as ORP-2, ORP2, DFNA67, DNFA67, oxysterol binding protein like 2

Oxysterol-binding protein-related protein 2 is a protein that in humans is encoded by the OSBPL2 gene.

Gene data

OSBPL2

Name: oxysterol binding protein like 2
Type: protein-coding
Position: 62,231,922–62,296,213 (+)
Aliases: DFNA67, DIDA, DNFA67, ORP-2, ORP2
Ensembl: ENSG00000130703
RefSeq RNA: NM_001001691.1, NM_001278649.3, NM_001363878.2, NM_014835.5, NM_144498.4
RefSeq protein: NP_001265578.1, NP_001350807.1, NP_055650.1, NP_653081.1

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014].

Pathways

Metabolism Synthesis of bile acids and bile salts Bile acid and bile salt metabolism Metabolism of lipids Metabolism of steroids

via MyGene.info

Wikidata facts

Image: 5zm8.jpg

Show 5 more facts

HomoloGene ID: 77324
exact match: identifiers.org/ncbigene/9885
genomic start: 60813580
genomic end: 60871268
cytogenetic location: 20q13.33

Sources (3)

via Wikidata · CC0

~1 min read

Article

2 sections

Contents

References
Further reading

Oxysterol-binding protein-related protein 2 is a protein that in humans is encoded by the OSBPL2 gene.

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.