OSBPL2
Sign in to saveAlso known as ORP-2, ORP2, DFNA67, DNFA67, oxysterol binding protein like 2
Oxysterol-binding protein-related protein 2 is a protein that in humans is encoded by the OSBPL2 gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to OSBPL2, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 20.
Vinony links it to 5 Wikipedia language editions.
Gene data
OSBPL2- Name
- oxysterol binding protein like 2
- Type
- protein-coding
- Position
- 62,231,922–62,296,213 (+)
- Aliases
- DFNA67, DIDA, DNFA67, ORP-2, ORP2
- Ensembl
- ENSG00000130703
- RefSeq RNA
- NM_001001691.1, NM_001278649.3, NM_001363878.2, NM_014835.5, NM_144498.4
- RefSeq protein
- NP_001265578.1, NP_001350807.1, NP_055650.1, NP_653081.1
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
oxysterol binding protein like 2
- Symbol
- OSBPL2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:62,231,922-62,296,213
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 5zm8.jpg
Show 7 more facts
- HomoloGene ID
- 77324
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9885
- chromosome
- human chromosome 20
- genomic start
- 60813580
- genomic end
- 60871268
- cytogenetic location
- 20q13.33
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Oxysterol-binding protein-related protein 2 is a protein that in humans is encoded by the OSBPL2 gene.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.
Excerpted from Wikipedia’s “OSBPL2” article, available under the CC BY-SA 4.0 licence.