OSBP2

Also known as HLM, ORP-4, ORP4, OSBPL1, OSBPL4, oxysterol binding protein 2

Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene.

In the Vinony graph

Within Vinony's link graph, OSBP2 is referenced by 3 other articles, and connects out to PubMed, human chromosome 22 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 22.

Its subject is documented across 5 Wikipedia language editions.

Gene data

OSBP2

Name: oxysterol binding protein 2
Type: protein-coding
Position: 30,693,782–30,907,824 (+)
Aliases: HLM, ORP-4, ORP2, ORP4, OSBPL1, OSBPL4
Ensembl: ENSG00000184792
RefSeq RNA: NM_001003812.1, NM_001282738.2, NM_001282739.2, NM_001282740.2, NM_001282741.2
RefSeq protein: NP_001269667.1, NP_001269668.1, NP_001269669.1, NP_001269670.1, NP_001269671.1

The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013].

Gene Ontology

Biological process

spermatid development

Molecular function

protein binding lipid binding cholesterol binding cholesterol binding sterol binding small molecule binding

Cellular component

acrosomal vesicle acrosomal vesicle cytosol plasma membrane membrane membrane perinuclear endoplasmic reticulum apical dendrite

via MyGene.info

Gene · Ensembl

oxysterol binding protein 2

Symbol: OSBP2
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:30,693,782-30,907,824
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 75303
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/23762
chromosome: human chromosome 22
genomic start: 31089769
genomic end: 31303811
cytogenetic location: 22q12.2

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene.

Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.

Excerpted from Wikipedia’s “OSBP2” article, available under the CC BY-SA 4.0 licence.