PAPOLA

Also known as PAP, poly(A) polymerase alpha, PAP-alpha

Poly(A) polymerase alpha is an enzyme that in humans is encoded by the PAPOLA gene.

In the Vinony graph

Vinony's link graph records 5 inbound references to PAPOLA, and connects out to Q180686, human chromosome 14 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 14.

Vinony links it to 6 Wikipedia language editions.

Gene data

PAPOLA

Name: poly(A) polymerase alpha
Type: protein-coding
Position: 96,501,433–96,567,118 (+)
Aliases: PAP, PAP-alpha
Ensembl: ENSG00000090060
RefSeq RNA: NM_001252006.1, NM_001252007.1, NM_001293627.1, NM_001293628.2, NM_001293632.3
RefSeq protein: NP_001238935.1, NP_001238936.1, NP_001280556.1, NP_001280557.1, NP_001280561.1

The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

Pathways

mRNA surveillance pathway - Homo sapiens (human)Disease Infectious disease mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination RNA Polymerase II Transcription Gene expression (Transcription)Processing of Capped Intronless Pre-mRNA Processing of Intronless Pre-mRNAs

via MyGene.info

Gene · Ensembl

poly(A) polymerase alpha

Symbol: PAPOLA
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:96,501,433-96,567,118
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein PAPOLA PDB 1f5a.png

Show 5 more facts

HomoloGene ID: 23389
exact match: identifiers.org/ncbigene/10914
genomic end: 96567116
genomic start: 96967770
cytogenetic location: 14q32.2

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

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Contents

References
Further reading

Poly(A) polymerase alpha is an enzyme that in humans is encoded by the PAPOLA gene.

PAPOLA binds to FIP1L1 (Factor interacting with PAPOLA and CPSF1), a subunit of the cleavage and polyadenylation specificity factor subunit 1 (CPSF1) complex. This complex polyadenylates the 3' end of precursor mRNAs (pre-mRNA) (see CPSF). CPSF1 is an RNA processing protein that binds to uracil-rich sequences in pre-mRNA, binds with and stimulates PAPOLA's Polynucleotide adenylyltransferase activity, and thereby adds adenylyl residues to pre-mRNA. This poly-adenylyl action increases pre mRNA's maturation and movement from the nucleus to cytoplasm while dramatically increasing the stability of the mRNA formed from pre-mRNA: FIP1L1 is a Pre-mRNA 3'-end-processing factor. FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or Retinoic acid receptor alpha (RARA) genes are causes of certain human diseases associated with pathologically increased levels of blood eosinophils and/or Leukemias.

Excerpted from Wikipedia’s “PAPOLA” article, available under the CC BY-SA 4.0 licence.