Structure via PubChem · Public domain (PubChem)
phentolamine
Sign in to saveAlso known as dibasin, fentolamin, Regitine®, Rogitine®, 2-(N-(m-hydroxyphenyl)-p-toluidinomethyl)imidazoline, Phentolamin, 2-(N-(m-Hydroxyphenyl)-P-toluidinomethyl)imidazoline, Phentolaminum
Phentolamine, sold under the brand name Regitine among others, is a non-selective α-adrenergic antagonist.
Key facts
- Drug.ChEBI
- 8081
- Drug.KEGG
- D08362
- Drug.ChEMBL
- 597
- Drug.C
- 17
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464200826
- Drug.image
- Phentolamine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 150
- Drug.image2
- Phentolamine-space-filling.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Regitine, OraVerse, Ryzumvi
- Drug.legal_US
- Rx-only
- Drug.routes_of_administration
- Intravenous, intramuscular, ophthalmic
- Drug.ATC_prefix
- C04
- Drug.ATC_suffix
- AB01
- Drug.ATC_supplemental
- ,
via Wikipedia infobox
Chemical data
- Formula
- C17H19N3O
- Molecular weight
- 281.35 g/mol
- IUPAC name
- 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol
- SMILES
- CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O
- InChIKey
- MRBDMNSDAVCSSF-UHFFFAOYSA-N
- XLogP
- 2.6
- Polar surface area
- 47.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1952
- Admin. routes
- parenteral, topical
- Indications
- cardiovascular disease, Hypoglycemia, obesity, Mydriasis
via ChEMBL · EBI
Research
13,859 papersvia PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 281.152812
- Has use
- medication
Show 7 more facts
- Commons category
- Phentolamine
- chemical formula
- C₁₇H₁₉N₃O
- defined daily dose
- 10
- medical condition treated
- arterial hypertension
- canonical SMILES
- CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O
- World Health Organisation international non-proprietary name
- phentolamine
- subject has role
- antihypertensive drug
via Wikidata · CC0
~3 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- Mechanism of action
- Chemistry
- References
Phentolamine, sold under the brand name Regitine among others, is a non-selective α-adrenergic antagonist.
==Medical uses== The primary application for phentolamine is for the control of hypertensive emergencies, most notably due to pheochromocytoma.
Excerpted from Wikipedia’s “phentolamine” article, available under the CC BY-SA 4.0 licence.