POLQ
Sign in to saveAlso known as POLH, PRO0327, polymerase (DNA) theta, DNA polymerase theta, DNA polymerase θ
DNA polymerase theta is an enzyme that in humans is encoded by the POLQ gene. This polymerase plays a key role in one of the three major double strand break repair pathways: theta-mediated end joining (TMEJ). Most double-strand breaks are repaired by non-homologous end joining (NHEJ) or homology directed repair (HDR). However, in some contexts, NHEJ and HR are insufficient and TMEJ is the only solution to repair the break.
Gene data
POLQ- Name
- DNA polymerase theta
- Type
- protein-coding
- Aliases
- PRO0327
Enables catalytic activity, acting on DNA; chromatin binding activity; and identical protein binding activity. Involved in DNA repair; negative regulation of double-strand break repair via homologous recombination; and protein homooligomerization. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 32727
- exact match
- identifiers.org/ncbigene/10721
- genomic end
- 121545988
- genomic start
- 121431431
- cytogenetic location
- 3q13.33
- Commons category
- DNA polymerase theta
Sources (3)
via Wikidata · CC0
~2 min read
Article
4 sectionsContents
- Polymerase theta's mutational signature
- Reverse transcription of RNA
- References
- Further reading
DNA polymerase theta is an enzyme that in humans is encoded by the POLQ gene. This polymerase plays a key role in one of the three major double strand break repair pathways: theta-mediated end joining (TMEJ). Most double-strand breaks are repaired by non-homologous end joining (NHEJ) or homology directed repair (HDR). However, in some contexts, NHEJ and HR are insufficient and TMEJ is the only solution to repair the break.
TMEJ is often described as alternative NHEJ, but differs in that it lacks a requirement for the Ku heterodimer, and it can only act on resected DNA ends. Following annealing of short (i.e., a few nucleotides) regions on the DNA overhangs, DNA polymerase theta catalyzes template-dependent DNA synthesis across the broken ends, stabilizing the paired structure.