پروسیکلیدین

Also known as 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol, 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol, 1-cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol, 1-cyclohexyl-1-phenyl-3-pyrrolidino-propan-1-ol, 1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol

Procyclidine is an anticholinergic drug principally used for the treatment of drug-induced parkinsonism, akathisia and acute dystonia, Parkinson's disease, and idiopathic or secondary dystonia.

Chemical data

Formula: C19H29NO
Molecular weight: 287.4 g/mol
IUPAC name: 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
SMILES: C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O
InChIKey: WYDUSKDSKCASEF-UHFFFAOYSA-N
XLogP: 4.1
Polar surface area: 23.5 Å²
H-bond donors: 1
H-bond acceptors: 2
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1955
Admin. routes: oral
Indications: Parkinson disease

via ChEMBL · EBI

Research

289 papers

Procyclidine abuse.The British journal of psychiatry : the journal of mental science · 1986
Dystonia.BMJ clinical evidence · 2014
Teenage procyclidine abuse.Lancet (London, England) · 1985
In vivo Evaluation of Antioxidant Activity of Chamomile Extract against Procyclidine-Induced Oxidative Stress: Potential Application in Cancer Prevention.Asian Pacific journal of cancer prevention : APJCP · 2024
Effects of procyclidine on eye movements in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2003

via PubMed

Wikidata facts

Subclass of: medication
Mass: 287.224915

Show 7 more facts

chemical formula: C₁₉H₂₉NO
medical condition treated: parkinsonian syndrome
canonical SMILES: C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O
World Health Organisation international non-proprietary name: procyclidine
subject has role: antiparkinson
Commons category: Procyclidine
defined daily dose: 25

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