Structure via PubChem · Public domain (PubChem)
procyclidine
Sign in to saveAlso known as 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol, 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol, 1-cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol, 1-cyclohexyl-1-phenyl-3-pyrrolidino-propan-1-ol, 1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol
Procyclidine is an anticholinergic drug principally used for the treatment of drug-induced parkinsonism, akathisia and acute dystonia, Parkinson's disease, and idiopathic or secondary dystonia.
In the Vinony graph
Within Vinony's link graph, procyclidine is referenced by 562 other articles, and connects out to cannabinoids, muscarinic antagonist and atropine.
Vinony files it under 1-Pyrrolidinyl compounds, Cyclohexyl compounds and Drugs with no legal status.
Its subject is documented across 12 Wikipedia language editions.
Chemical data
- Formula
- C19H29NO
- Molecular weight
- 287.4 g/mol
- IUPAC name
- 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
- SMILES
- C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O
- InChIKey
- WYDUSKDSKCASEF-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 23.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1955
- Admin. routes
- oral
- Indications
- Parkinson disease
via ChEMBL · EBI
Research
289 papers- Procyclidine abuse.The British journal of psychiatry : the journal of mental science · 1986
- Dystonia.BMJ clinical evidence · 2014
- Teenage procyclidine abuse.Lancet (London, England) · 1985
- In vivo Evaluation of Antioxidant Activity of Chamomile Extract against Procyclidine-Induced Oxidative Stress: Potential Application in Cancer Prevention.Asian Pacific journal of cancer prevention : APJCP · 2024
- Effects of procyclidine on eye movements in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2003
via PubMed
Wikidata facts
- Subclass of
- medication
- Mass
- 287.224915
Show 7 more facts
- chemical formula
- C₁₉H₂₉NO
- medical condition treated
- parkinsonian syndrome
- canonical SMILES
- C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O
- World Health Organisation international non-proprietary name
- procyclidine
- subject has role
- antiparkinson
- Commons category
- Procyclidine
- defined daily dose
- 25
via Wikidata · CC0
~4 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Side effects
- Overdose
- Pharmacology
- Pharmacodynamics
- Chemistry
- Synthesis
- See also
- References
- Further reading
Procyclidine is an anticholinergic drug principally used for the treatment of drug-induced parkinsonism, akathisia and acute dystonia, Parkinson's disease, and idiopathic or secondary dystonia.
== Medical uses == It is used in patients with parkinsonism and akathisia, and to reduce the side effects of antipsychotic treatment given for schizophrenia. Procyclidine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor but not rigidity or bradykinesia.
Excerpted from Wikipedia’s “procyclidine” article, available under the CC BY-SA 4.0 licence.