propacetamol
Sign in to savePropacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered by I.V. It is given if the patient is unable to take oral or rectally delivered paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated. The onset of analgesia from propacetamol is more rapid than paracetamol given orally. 2 grams of propacetamol are equivalent to 1g of paracetamol.
Research
208 papers- Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain.The Cochrane database of systematic reviews · 2016
- Pediatric intravenous paracetamol (propacetamol) pharmacokinetics: a population analysis.Paediatric anaesthesia · 2005
- Single dose intravenous propacetamol or intravenous paracetamol for postoperative pain.The Cochrane database of systematic reviews · 2011
- Propacetamol in dogs: First description of its pharmacokinetics after intravenous and oral administration.Research in veterinary science · 2022
- [Propacetamol: from basic action to clinical utilization].Annales francaises d'anesthesie et de reanimation · 1999
via PubMed
Wikidata facts
- Mass
- 264.147393
Show 4 more facts
- chemical formula
- C₁₄H₂₀N₂O₃
- defined daily dose
- 6
- canonical SMILES
- CCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C
- Commons category
- Propacetamol
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Article
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Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered by I.V. It is given if the patient is unable to take oral or rectally delivered paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated. The onset of analgesia from propacetamol is more rapid than paracetamol given orally. 2 grams of propacetamol are equivalent to 1g of paracetamol.
== See also == Phenacetin