Structure via PubChem · Public domain (PubChem)
propacetamol
Sign in to savePropacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered by I.V. It is given if the patient is unable to take oral or rectally delivered paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated. The onset of analgesia from propacetamol is more rapid than paracetamol given orally. 2 grams of propacetamol are equivalent to 1g of paracetamol.
Chemical data
- Formula
- C14H20N2O3
- Molecular weight
- 264.32 g/mol
- IUPAC name
- (4-acetamidophenyl) 2-(diethylamino)acetate
- SMILES
- CCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C
- InChIKey
- QTGAJCQTLIRCFL-UHFFFAOYSA-N
- XLogP
- 1.1
- Polar surface area
- 58.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- pain, Fever
via ChEMBL · EBI
Research
208 papers- Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain.The Cochrane database of systematic reviews · 2016
- Pediatric intravenous paracetamol (propacetamol) pharmacokinetics: a population analysis.Paediatric anaesthesia · 2005
- Single dose intravenous propacetamol or intravenous paracetamol for postoperative pain.The Cochrane database of systematic reviews · 2011
- Propacetamol in dogs: First description of its pharmacokinetics after intravenous and oral administration.Research in veterinary science · 2022
- [Propacetamol: from basic action to clinical utilization].Annales francaises d'anesthesie et de reanimation · 1999
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 264.147393
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₄H₂₀N₂O₃
- defined daily dose
- 6
- canonical SMILES
- CCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C
- subject has role
- analgesic
- Commons category
- Propacetamol
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered by I.V. It is given if the patient is unable to take oral or rectally delivered paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated. The onset of analgesia from propacetamol is more rapid than paracetamol given orally. 2 grams of propacetamol are equivalent to 1g of paracetamol.
== See also == Phenacetin
Excerpted from Wikipedia’s “propacetamol” article, available under the CC BY-SA 4.0 licence.