peptic ulcer disease
Also known as acute peptic ulcer with hemorrhage, acute peptic ulcer with hemorrhage and perforation, acute peptic ulcer without hemorrhage AND without perforation (disorder), acute peptic ulcer without hemorrhage and without perforation, Stomach Ulcers, peptic ulcer, gastroduodenal ulcer, gastro-duodenal ulcer
ulcer of an area of the gastrointestinal tract
AI overview
Peptic ulcer disease is a condition where sores develop in the lining of the stomach or small intestine. These ulcers can cause pain and, if left untreated, may lead to serious complications like bleeding.
AI-generated from the Wikipedia summary — may contain errors.
Research
91,781 papers- Diagnosis and Treatment of Peptic Ulcer Disease.ReviewThe American journal of medicine · 2019Kavitt RT, Lipowska AM, Anyane-Yeboa A et al.DOI: 10.1016/j.amjmed.2018.12.009
- Peptic Ulcer Disease.ReviewPrimary care · 2023Tuerk E, Doss S, Polsley KDOI: 10.1016/j.pop.2023.03.003
- Peptic Ulcer Disease and Helicobacter pylori infection.ReviewMissouri medicine · 2018Narayanan M, Reddy KM, Marsicano E
- Peptic-ulcer disease.ReviewLancet (London, England) · 2002Chan FK, Leung WKDOI: 10.1016/s0140-6736(02)11030-0
Article
Peptic ulcer disease refers to damage of the inner part of the stomach's gastric mucosa (lining of the stomach), the first part of the small intestine, or sometimes the lower esophagus. An ulcer in the stomach is called a gastric ulcer, while one in the first part of the intestines is a duodenal ulcer. The most common symptoms of a duodenal ulcer are waking at night with upper abdominal pain, and upper abdominal pain that improves with eating. With a gastric ulcer, the pain may worsen with eating. The pain is often described as a burning or dull ache. Other symptoms include belching, vomiting, weight loss, or poor appetite. About a third of older people with peptic ulcers have no symptoms. Complications may include bleeding, perforation, and blockage of the stomach. Bleeding occurs in as many as 15% of cases.
Common causes include infection with Helicobacter pylori and excessive use of non-steroidal anti-inflammatory drugs (NSAIDs). Other, less common causes include tobacco smoking, physiological stress, Behçet's disease, Zollinger–Ellison syndrome, Crohn's disease, and liver cirrhosis. Older people are more sensitive to the ulcer-causing effects of NSAIDs. The diagnosis is typically suspected due to the presenting symptoms with confirmation by either endoscopy or barium swallow. H. pylori can be diagnosed by testing the blood for antibodies, a urea breath test, testing the stool for signs of the bacteria, or a biopsy of the stomach. Other conditions that produce similar symptoms include stomach cancer, coronary heart disease, and inflammation of the stomach lining or gallbladder inflammation.