pyridoxamine
Sign in to saveAlso known as 4-(aminomethyl)-5-(hydroxymethyl)-2-methyl-pyridin-3-ol, 4-(aminomethyl)-2-methyl-5-methylol-pyridin-3-ol, 4-(Aminomethyl)-5-(hydroxymethyl)-2-methyl-3-pyridinol, 2-Methyl-4-aminomethyl-5-hydroxymethyl-3-Pyridinol, Pyridoxylamine, 4-(Aminomethyl)-5-hydroxy-6-methyl-3-Pyridinemethanol
Pyridoxamine (PM) is one form of vitamin B6. Chemically it is based on a pyridine ring structure, with hydroxyl, methyl, aminomethyl, and hydroxymethyl substituents. It differs from pyridoxine by the substituent at the 4-position. The hydroxyl at position 3 and aminomethyl group at position 4 of its ring endow pyridoxamine with a variety of chemical properties, including the scavenging of free radical species and carbonyl species formed in sugar and lipid degradation and chelation of metal ions that catalyze Amadori reactions.
Research
1,555 papers- Pyridoxamine: another vitamin for sickle cell disease?Haematologica · 2020
- Pyridoxamine (BioStratum).Current opinion in investigational drugs (London, England : 2000) · 2005
- Pyridoxamine: the many virtues of a maillard reaction inhibitor.Annals of the New York Academy of Sciences · 2005
- Pyridoxamine as a multifunctional pharmaceutical: targeting pathogenic glycation and oxidative damage.Cellular and molecular life sciences : CMLS · 2005
- Pyridoxamine treatment ameliorates large artery stiffening and cerebral artery endothelial dysfunction in old mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
via PubMed
Wikidata facts
- Subclass of
- vitamin B6
- Mass
- 168.09
Show 5 more facts
- chemical formula
- C₈H₁₂N₂O₂
- found in taxon
- Escherichia coli
- canonical SMILES
- CC1=NC=C(C(=C1O)CN)CO
- subject has role
- primary metabolite
- Commons category
- Pyridoxamine
via Wikidata · CC0
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Encyclopedic overview
5 sectionsContents
- Research
- FDA Regulatory Activity
- See also
- References
- External links
Pyridoxamine (PM) is one form of vitamin B6. Chemically it is based on a pyridine ring structure, with hydroxyl, methyl, aminomethyl, and hydroxymethyl substituents. It differs from pyridoxine by the substituent at the 4-position. The hydroxyl at position 3 and aminomethyl group at position 4 of its ring endow pyridoxamine with a variety of chemical properties, including the scavenging of free radical species and carbonyl species formed in sugar and lipid degradation and chelation of metal ions that catalyze Amadori reactions.
==Research== Pyridoxamine can form fairly weak complexes with a number of transition metal ions, with a preference for Cu2+ and Fe3+. The 3'-hydroxyl group of pyridoxamine allows for efficient hydroxyl radical scavenging.
Excerpted from Wikipedia’s “pyridoxamine” article, available under the CC BY-SA 4.0 licence.