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(R)-amphetamine

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Also known as l-amphetamine, levoamphetamine

Levoamphetamine is a stimulant medication which is used in the treatment of certain medical conditions. It was previously marketed by itself under the brand name Cydril, but is now available only in combination with dextroamphetamine in varying ratios under brand names such as Adderall. The drug is known to increase wakefulness and concentration in association with decreased appetite and fatigue. Pharmaceuticals that contain levoamphetamine are currently indicated and prescribed for the treatment of attention deficit hyperactivity disorder (ADHD), obesity, and narcolepsy in some countries. Lev

Key facts

Drug.INN
Levamfetamine
Drug.image
Levoamphetamine.svg
Drug.image_class
skin-invert-image
Drug.width
200px
Drug.image2
Cydril.png
Drug.image_class2
bg-transparent
Drug.width2
200px
Drug.tradename
Cydril, others
Drug.legal_US
Schedule II
Drug.legal_status
SE: Förteckning II
Drug.routes_of_administration
Oral (as part of Adderall, Evekeo, and generic amphetamine)
Drug.class
Stimulant; Norepinephrine releasing agent
Drug.protein_bound
31.7%
Drug.metabolism
Hydroxylation (CYP2D6), oxidative deamination
Drug.metabolites
L-4-Hydroxyamphetamine
Drug.elimination_half life
11.7–15.2hours
Drug.excretion
Urine
Drug.CAS_number
156-34-3

via Wikipedia infobox

~21 min read

Encyclopedic overview

25 sections
Contents
  • Medical uses
  • Available forms
  • Racemic amphetamine
  • Adderall
  • Evekeo
  • Other forms
  • Side effects
  • Pharmacology
  • Pharmacodynamics
  • Pharmacokinetics
  • Absorption
  • Distribution
  • Metabolism
  • Elimination
  • Chemistry
  • History
  • Society and culture
  • Legal status
  • Recreational use
  • Research
  • Other drugs
  • Selegiline
  • Notes
  • References
  • External links

Levoamphetamine is a stimulant medication which is used in the treatment of certain medical conditions. It was previously marketed by itself under the brand name Cydril, but is now available only in combination with dextroamphetamine in varying ratios under brand names such as Adderall. The drug is known to increase wakefulness and concentration in association with decreased appetite and fatigue. Pharmaceuticals that contain levoamphetamine are currently indicated and prescribed for the treatment of attention deficit hyperactivity disorder (ADHD), obesity, and narcolepsy in some countries. Levoamphetamine is taken by mouth.

Levoamphetamine acts as a releasing agent of the monoamine neurotransmitters norepinephrine and dopamine. It is similar to dextroamphetamine in its ability to release norepinephrine and in its sympathomimetic effects but is a few times weaker than dextroamphetamine in its capacity to release dopamine and in its psychostimulant effects. Levoamphetamine is the levorotatory stereoisomer of the racemic amphetamine molecule, whereas dextroamphetamine is the dextrorotatory isomer.

Excerpted from Wikipedia’s “(R)-amphetamine” article, available under the CC BY-SA 4.0 licence.