REG3A

Also known as HIP, HIP/PAP, INGAP, PAP, PAP-H, PAP1, PBCGF, REG-III

Regenerating islet-derived protein 3 alpha (or Regenerating islet-derived protein III-alpha) formerly known as HIP/PAP (Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-Associated Protein) and peptide 23 is a protein that in humans is encoded by the REG3A gene.

Gene data

REG3A

Name: regenerating family member 3 alpha
Type: protein-coding
Position: 79,157,003–79,159,753 (−)
Aliases: HIP, HIP/PAP, INGAP, PAP, PAP-H, PAP1, PBCGF, REG-III, REG3
Ensembl: ENSG00000172016
RefSeq RNA: NM_002580.3, NM_138937.3, NM_138938.3
RefSeq protein: NP_002571.1, NP_620354.1, NP_620355.1

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014].

Pathways

Innate Immune System Immune System Antimicrobial peptides

via MyGene.info

Wikidata facts

Image: Protein REG3A PDB 1uv0.png

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HomoloGene ID: 130506
exact match: identifiers.org/ncbigene/5068
genomic end: 79386879
genomic start: 79384132
cytogenetic location: 2p12

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This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Multiple alternatively spliced transcript variants encoding the same protein have been described for this gene but the full length nature of some transcripts is not yet known.