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renin
ProteinQ258915· pop 44· linked from 392 articles

renin

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Also known as angiotensinogenase, angiotensin-forming enzyme, REN, renin precursor, renal

Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS), which increases the volume of extracellular fluid (blood plasma, lymph, and interstitial fluid) and causes arterial vasoconstriction. Thus, it increases the body's mean arterial blood pressure.

OverviewAI-generated

Renin is a protein encoded by the REN gene in *Homo sapiens*. The protein consists of 406 amino acids and has a mass of 45057. It is classified as an aspartyl protease and undergoes alternative splicing. The protein structure is characterized by cleavage on a pair of basic residues. Evidence for the existence of renin is present at the protein level, and its three-dimensional structure has been determined through direct protein sequencing.

Synthesized by Vinony from 16 facts across 5 sources: Wikidata, PubMed, ClinicalTrials.gov, UniProt, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Key facts

Enzyme.Name
renin
Enzyme.EC_number
3.4.23.15
Enzyme.CAS_number
9015-94-5
Enzyme.GO_code
0004195

via Wikipedia infobox

Protein · UniProt

Renin

Gene
REN
Organism
Homo sapiens (Human)
Length
406 aa
Molecular mass
45,057 Da
Evidence
1: Evidence at protein level

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney

3D-structureAlternative splicingAspartyl proteaseCleavage on pair of basic residuesDirect protein sequencingDisease variantDisulfide bondGlycoprotein
View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Research

74,197 papers

via PubMed

Clinical Trials

299 registered

via ClinicalTrials.gov

~8 min read

Encyclopedic overview

13 sections
Contents
  • Biochemistry and physiology
  • Structure
  • Secretion
  • Renin–angiotensin system
  • Function
  • Genetics
  • Clinical applications
  • Measurement
  • Discovery and naming
  • See also
  • References
  • Further reading
  • External links

Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS), which increases the volume of extracellular fluid (blood plasma, lymph, and interstitial fluid) and causes arterial vasoconstriction. Thus, it increases the body's mean arterial blood pressure.

Renin is not commonly referred to as a hormone, although it has a receptor, the (pro)renin receptor, also known as the renin receptor and prorenin receptor (see also below), as well as enzymatic activity with which it hydrolyzes angiotensinogen to angiotensin I.

Excerpted from Wikipedia’s “renin” article, available under the CC BY-SA 4.0 licence.

Gallery (2)

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