Structure via PubChem · Public domain (PubChem)
rottlerin
Sign in to saveAlso known as mallotoxin, Kamalin, 3'-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl)-2',4',6'-trihydroxy-5'-methyl-acetophenone
Rottlerin (mallotoxin) is a polyphenol natural product isolated from the Asian tree Mallotus philippensis. Rottlerin displays a complex spectrum of pharmacology.
Chemical data
- Formula
- C30H28O8
- Molecular weight
- 516.5 g/mol
- IUPAC name
- (E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one
- SMILES
- CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C(=C3C(=C2O)C=CC(O3)(C)C)C(=O)/C=C/C4=CC=CC=C4)O)O
- InChIKey
- DEZFNHCVIZBHBI-ZHACJKMWSA-N
- XLogP
- 5.9
- Polar surface area
- 145 Ų
- H-bond donors
- 5
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 516.178418
Show 6 more facts
- chemical formula
- C₃₀H₂₈O₈
- found in taxon
- Mallotus philippensis
- isomeric SMILES
- CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)/C=C/C4=CC=CC=C4)OC(C=C3)(C)C)O)O
- canonical SMILES
- CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)C=CC4=CC=CC=C4)OC(C=C3)(C)C)O)O
- subject has role
- enzyme inhibitor
- physically interacts with
- Potassium voltage-gated channel subfamily H member 2
via Wikidata · CC0
~5 min read
Encyclopedic overview
10 sectionsContents
- Effects
- Uncoupler of oxidative phosphorylation
- Potassium channel opener
- Role in cardioplegia reperfusion
- Contractility and vascular effects
- Akt activation
- Antioxidant properties
- Ineffective PKCδ selective inhibitor
- Sources
- References
Rottlerin (mallotoxin) is a polyphenol natural product isolated from the Asian tree Mallotus philippensis. Rottlerin displays a complex spectrum of pharmacology.
== Effects ==
Excerpted from Wikipedia’s “rottlerin” article, available under the CC BY-SA 4.0 licence.