Structure via PubChem · Public domain (PubChem)
(RS)-etodolac
Sign in to saveAlso known as AY-24236, 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid, 1,3,4,9-tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid, (+-)-1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid, (1,8-diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid
Etodolac is a nonsteroidal anti-inflammatory drug (NSAID).
Chemical data
- Formula
- C17H21NO3
- Molecular weight
- 287.35 g/mol
- IUPAC name
- 2-(1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
- SMILES
- CCC1=C2C(=CC=C1)C3=C(N2)C(OCC3)(CC)CC(=O)O
- InChIKey
- NNYBQONXHNTVIJ-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 62.3 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
4 papers- Liquid chromatographic enantioseparation of (RS)-etodolac using (S)-levofloxacin and determination of absolute configuration of the diastereomeric derivatives.Biomedical chromatography : BMC · 2019
- A novel approach for enantioseparation as applied to (RS)-etodolac from pharmaceutical formulations: LC MS and density functional theory support for confirmation of diastereomers so separated.Biomedical chromatography : BMC · 2015
- HPLC enantioseparation of racemic bupropion, baclofen and etodolac: modification of conventional ligand exchange approach by pre-column formation of chiral ligand exchange complexes.Biomedical chromatography : BMC · 2016
- Ligand Exchange Thin Layer Chromatographic Enantioresolution of (RS)-Ketorolac and (RS)-Etodolac and Recovery of Native Enantiomers.Journal of chromatographic science · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 287.152
- Has use
- medication
Show 9 more facts
- Commons category
- Etodolac
- chemical formula
- C₁₇H₂₁NO₃
- medical condition treated
- osteoarthritis
- World Health Organisation international non-proprietary name
- etodolac
- canonical SMILES
- CCC1=CC=CC2=C1NC3=C2CCOC3(CC)CC(=O)O
- defined daily dose
- 0.4
- physically interacts with
- Prostaglandin-endoperoxide synthase 2
- significant drug interaction
- tacrolimus
- legal status (medicine)
- boxed warning
Sources (11)
via Wikidata · CC0
~4 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Interactions
- Pregnancy and nursing
- Brand names
- References
- External links
Etodolac is a nonsteroidal anti-inflammatory drug (NSAID).
It was patented in 1971 and approved for medical use in 1985. It was approved in the U.S. in 1991.
Excerpted from Wikipedia’s “(RS)-etodolac” article, available under the CC BY-SA 4.0 licence.