(RS)-metoprolol

Metoprolol, sold under the brand names Lopressor and Toprol-XL among others, is a medication used to treat angina, high blood pressure and a number of conditions involving an abnormally fast heart rate. It is also used to prevent further heart problems after myocardial infarction and to prevent headaches in those with migraines. It is a beta blocker, specifically a selective β1 receptor blocker, and is taken by mouth or is given intravenously.

Key facts

Drug.O: 3
Drug.Watchedfields: changed
Drug.verifiedrevid: 459444186
Drug.image: Metoprolol structure.svg
Drug.image_class: skin-invert-image
Drug.image2: Metoprolol_ball-and-stick.png
Drug.image_class2: bg-transparent
Drug.chirality: Racemic mixture
Drug.pronounce: ,
Drug.tradename: Lopressor (metoprolol tartrate), Toprol-XL (metoprolol succinate)
Drug.MedlinePlus: a682864
Drug.DailyMedID: Metoprolol
Drug.pregnancy_AU

Article

17 sections

Contents

Medical uses
Adverse effects
Precautions
Pregnancy and breastfeeding
Overdose
Pharmacology
Mechanism of action
Pharmacokinetics
Chemistry
Stereochemistry
Formulations
Society and culture
Legal status
Economics
Sports
References
Further reading

Common side effects include trouble sleeping, feeling tired, feeling faint, and abdominal discomfort. Large doses may cause serious toxicity. Risk in pregnancy has not been ruled out. It appears to be safe in breastfeeding. The metabolism of metoprolol can vary widely among patients, often as a result of hepatic impairment or CYP2D6 polymorphism.