SERPINE2
Sign in to saveAlso known as GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI, serpin family E member 2
Glia-derived nexin is a protein that in humans is encoded by the SERPINE2 gene.
Gene data
SERPINE2- Name
- serpin family E member 2
- Type
- protein-coding
- Position
- 223,975,045–224,039,688 (−)
- Aliases
- GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI
- Ensembl
- ENSG00000135919
- RefSeq RNA
- NM_001136528.2, NM_001136530.1, NM_006216.4, NR_073116.2, XM_005246641.3
- RefSeq protein
- NP_001130000.1, NP_001130002.1, NP_006207.1, XP_005246698.1, XP_016859819.1
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Gene Ontology
Biological process
negative regulation of platelet activationnegative regulation of plasminogen activationnegative regulation of plasminogen activationnegative regulation of plasminogen activationnegative regulation of protein processingnegative regulation of blood coagulationnegative regulation of blood coagulationnegative regulation of blood coagulation
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
serpin family E member 2
- Symbol
- SERPINE2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:223,975,045-224,039,688
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 21247
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5270
- chromosome
- human chromosome 2
- genomic start
- 223975045
- genomic end
- 224039318
- cytogenetic location
- 2q36.1
Sources (4)
via Wikidata · CC0