SIN3A
Sign in to saveAlso known as Paired amphipathic helix protein Sin3a, SIN3 transcription regulator family member A, WITKOS
gen de la especie Homo sapiens
Gene data
SIN3A- Name
- SIN3 transcription regulator family member A
- Type
- protein-coding
- Position
- 75,369,379–75,455,842 (−)
- Aliases
- CHR15DELq24, DEL15Q24, WITKOS
- Ensembl
- ENSG00000169375
- RefSeq RNA
- NM_001145357.2, NM_001145358.2, NM_001437462.1, NM_001437463.1, NM_015477.3
- RefSeq protein
- NP_001138829.1, NP_001138830.1, NP_001424391.1, NP_001424392.1, NP_056292.1
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SIN3 transcription regulator family member A
- Symbol
- SIN3A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:75,369,379-75,455,842
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
635 papers- Regulation of the Methylation and Expression Levels of the BMPR2 Gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension.Circulation · 2021
- Sin3a drives mesenchymal-to-epithelial transition through cooperating with Tet1 in somatic cell reprogramming.Stem cell research & therapy · 2022
- SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability.Cell reports · 2024
- Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis.American journal of respiratory and critical care medicine · 2021
- Suppression of SIN3A by miR-183 Promotes Breast Cancer Metastasis.Molecular cancer research : MCR · 2022
via PubMed
Wikidata facts
- Instance of
- gene
- Image
- Protein SIN3A PDB 1g1e.png
Show 7 more facts
- HomoloGene ID
- 32124
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/25942
- genomic end
- 75748183
- genomic start
- 75661720
- chromosome
- human chromosome 15
- cytogenetic location
- 15q24.2
via Wikidata · CC0
Article · Español
La proteína con hélices emparejadas anfipáticas (SIN3A) es una proteína codificada en humanos por el gen SIN3A. La proteína codificada por este gen es un regulador de la transcripción. Contiene dominios de hélices emparejadas anfipáticas (PAH), que juegan un importante papel en la interacción proteína-proteína y podría mediar en la represión ejercida por el complejo Mad-Max.
Abstract from DBpedia / Wikipedia · CC BY-SA