SLX4
Sign in to saveAlso known as BTBD12, FANCP, MUS312, SLX4 structure-specific endonuclease subunit
SLX4 (also known as BTBD12 and FANCP) is a protein involved in DNA repair, where it has important roles in the final steps of homologous recombination. Mutations in the gene are associated with the disease Fanconi anemia.
Gene data
SLX4- Name
- SLX4 structure-specific endonuclease subunit
- Type
- protein-coding
- Aliases
- BTBD12, FANCP, MUS312
This gene encodes a protein that functions as an assembly component of multiple structure-specific endonucleases. These endonuclease complexes are required for repair of specific types of DNA lesions and critical for cellular responses to replication fork failure. Mutations in this gene were found in patients with Fanconi anemia. [provided by RefSeq, Sep 2016].
via MyGene.info
Gene · Ensembl
SLX4 structure-specific endonuclease subunit
- Symbol
- SLX4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:3,579,654-3,611,617
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 23770
- exact match
- identifiers.org/ncbigene/84464
- genomic end
- 3611606
- genomic start
- 3631182
- cytogenetic location
- 16p13.3
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- External links
SLX4 (also known as BTBD12 and FANCP) is a protein involved in DNA repair, where it has important roles in the final steps of homologous recombination. Mutations in the gene are associated with the disease Fanconi anemia.
The version of SLX4 present in humans and other mammals acts as a sort of scaffold upon which other proteins form several different multiprotein complexes. The SLX1-SLX4 complex acts as a Holliday junction resolvase. As such, the complex cleaves the links between two homologous chromosomes that form during homologous recombination. This allows the two linked chromosomes to resolve into two unconnected double-strand DNA molecules. The SLX4 interacting protein interacts with SLX4 in the DNA repair process, specifically in interstrand crosslink repair. SLX4 also associates with RAD1, RAD10 and SAW1 in the single-strand annealing pathway of homologous recombination. The DNA repair function of SLX4 is involved in sensitivity to proton beam radiation.