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GeneQ18031703· pop 5· linked from 821 articles

SREBF2

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Also known as SREBP-2, SREBP2, bHLHd2, sterol regulatory element binding transcription factor 2

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 821 inbound references to SREBF2, and connects out to PubMed, homeobox and Ensembl genome database project.

Vinony files it under Genes on human chromosome 22 and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

SREBF2

Name: sterol regulatory element binding transcription factor 2
Type: protein-coding
Position: 41,833,029–41,907,308 (+)
Aliases: SREBP-2, SREBP2, bHLHd2
Ensembl: ENSG00000198911
RefSeq RNA: NM_004599.4, NR_103834.2, XM_011530347.3, XM_017028921.3, XM_017028922.3
RefSeq protein: NP_004590.2, XP_011528649.1, XP_016884410.1, XP_016884411.1, XP_054181847.1

This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II lipid metabolic process cholesterol metabolic process regulation of Notch signaling pathway cellular response to starvation

Molecular function

C-8 sterol isomerase activity transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific

Cellular component

Golgi membrane Golgi membrane Golgi membrane chromatin nucleus nucleus nucleus nucleus

Pathways

Developmental Biology Developmental Biology Metabolism Metabolism Regulation of cholesterol biosynthesis by SREBP (SREBF)Regulation of cholesterol biosynthesis by SREBP (SREBF)Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)Activation of gene expression by SREBF (SREBP)

via MyGene.info

Gene · Ensembl

sterol regulatory element binding transcription factor 2

Symbol: SREBF2
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:41,833,029-41,907,308
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein SREBF2 PDB 1ukl.png

Show 7 more facts

HomoloGene ID: 20966
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/6721
genomic end: 41907307
genomic start: 42229109
chromosome: human chromosome 22
cytogenetic location: 22q13.2

Sources (4)

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Categories

Genes on human chromosome 22 Transcription factors