Structure via PubChem · Public domain (PubChem)
sulfinpyrazone
Sign in to saveAlso known as ANR315, Anturane®, Apo-sulfinpyrazone®, G 28315, NSC 75925, suphinpyrazone, Sulfoxyphenylpyrazolidine, 4-(2-Benzenesulfinylethyl)-1,2-diphenylpyrazolidine-3,5-dione
Sulfinpyrazone is a uricosuric medication used to treat gout. It also sometimes is used to reduce platelet aggregation by inhibiting degranulation of platelets which reduces the release of ADP and thromboxane.
Chemical data
- Formula
- C23H20N2O3S
- Molecular weight
- 404.5 g/mol
- IUPAC name
- 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione
- SMILES
- C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4
- InChIKey
- MBGGBVCUIVRRBF-UHFFFAOYSA-N
- XLogP
- 2.3
- Polar surface area
- 76.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1959
- Admin. routes
- oral
- Indications
- gout
via ChEMBL · EBI
Research
1,309 papers- Sulfinpyrazone: a review of its pharmacological properties and therapeutic use.Drugs · 1980
- Sulfinpyrazone: relationship between dose, kinetics, plasma concentrations and biological effects.Thrombosis research. Supplement · 1983
- Sulfinpyrazone alone?Circulation · 1981
- Sulfinpyrazone after myocardial infarction.The Medical journal of Australia · 1980
- Sulfinpyrazone after myocardial infarction?The Medical journal of Australia · 1978
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 404.119464
- Has use
- medication
Show 7 more facts
- chemical formula
- C₂₃H₂₀N₂O₃S
- World Health Organisation international non-proprietary name
- sulfinpyrazone
- medical condition treated
- angina pectoris
- canonical SMILES
- C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4
- defined daily dose
- 0.3
- physically interacts with
- Solute carrier family 22 member 12
- Commons category
- Sulfinpyrazone
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Contraindications
- Research
- References
Sulfinpyrazone is a uricosuric medication used to treat gout. It also sometimes is used to reduce platelet aggregation by inhibiting degranulation of platelets which reduces the release of ADP and thromboxane.
Like other uricosurics, sulfinpyrazone works by competitively inhibiting uric acid reabsorption in the proximal tubule of the kidney.
Excerpted from Wikipedia’s “sulfinpyrazone” article, available under the CC BY-SA 4.0 licence.
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