taxane
Sign in to saveTaxanes are a class of diterpenes. They were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer.
~2 min read
Encyclopedic overview
7 sectionsContents
- Production
- Mechanism of action
- Substances
- Names
- See also
- References
- External links
Taxanes are a class of diterpenes. They were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer.
Taxanes present difficulties in formulation as medicines because they are poorly soluble in water.
Excerpted from Wikipedia’s “taxane” article, available under the CC BY-SA 4.0 licence.