terfenadine
Sign in to saveAlso known as RMI-9918, Seldane®, Triludan®, (RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-ol, Terfénadine, Terfenadina, Terfenadin
Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi) and was marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. It was superseded by its active metabolite fexofenadine in the 1990s due to the risk of a particular type of disruption of the electrical rhythms of the heart (specifically cardiac arrhythmia caused by QT interval prolongation) and has been withdrawn from most of markets worldwide.
Research
2,310 papers- Terfenadine, a nonsedating antihistamine.Drug intelligence & clinical pharmacy · 1985
- Terfenadine. The first nonsedating antihistamine.Clinical reviews in allergy · 1993
- Terfenadine. A review of its pharmacodynamic properties and therapeutic efficacy.Drugs · 1985
- Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequences.Clinical pharmacokinetics · 1994
- Terfenadine. An updated review of its pharmacological properties and therapeutic efficacy.Drugs · 1990
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 471.31373
- Has use
- medication
Show 7 more facts
- significant drug interaction
- thioridazine
- chemical formula
- C₃₂H₄₁NO₂
- canonical SMILES
- CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O
- defined daily dose
- 0.12
- MCN code
- 2933.39.31
- physically interacts with
- Potassium voltage-gated channel subfamily H member 2
- Commons category
- Terfenadine
via Wikidata · CC0
~6 min read
Encyclopedic overview
4 sectionsContents
- Medical uses
- Pharmacology
- History
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470602363 | IUPAC_name = (RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-ol | image = Terfenadine.svg | image_class = skin-invert-image | width = 250px
| tradename = Seldane, Triludan, Teldane | Drugs.com = | MedlinePlus = a600034 | pregnancy_US = C | legal_status = Withdrawn in most of the worldPrescription only in China | routes_of_administration = By mouth
Excerpted from Wikipedia’s “terfenadine” article, available under the CC BY-SA 4.0 licence.