Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi) and was marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. It was superseded by its active metabolite fexofenadine in the 1990s due to the risk of a particular type of disruption of the electrical rhythms of the heart (specifically cardiac arrhythmia caused by QT interval prolongation) and has been withdrawn from most of markets worldwide.
via PubMed
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470602363 | IUPAC_name = (RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-ol | image = Terfenadine.svg | image_class = skin-invert-image | width = 250px
| tradename = Seldane, Triludan, Teldane | Drugs.com = | MedlinePlus = a600034 | pregnancy_US = C | legal_status = Withdrawn in most of the worldPrescription only in China | routes_of_administration = By mouth
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).