Plasminogen activator, tissue type

Protein · UniProt

Tissue-type plasminogen activator

Gene

PLAT

Organism

Homo sapiens (Human)

Length

562 aa

Molecular mass

62,917 Da

Evidence

1: Evidence at protein level

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity)

• PHASE2COMPLETED
  Efficacy and Safety of SP-8203 in Patients With Ischemic Stroke Requiring rtPAShin Poong Pharmaceutical Co. Ltd. · NCT04479449
• PHASE2COMPLETED
  Thrombolysis and Deferoxamine in Middle Cerebral Artery OcclusionGermans Trias i Pujol Hospital · NCT00777140
• PHASE3RECRUITING
  Efficacy and Safety of SP-8203 (Otaplimastat) in Patients With Acute Ischemic Stroke Receiving Thrombolytic Standard of CareShin Poong Pharmaceutical Co. Ltd. · NCT06660719
• COMPLETED
  Assessment of Hemostasis Disorders in rtPA-treated Patients Requiring Endovascular Treatment for Ischemic StrokeFondation Ophtalmologique Adolphe de Rothschild · NCT02893631
• PHASE4COMPLETED
  Low Dosage of rt-PA in the Treatment of Pulmonary Thromboembolism in ChinaBeijing Chao Yang Hospital · NCT00781378
• PHASE3WITHDRAWN
  Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes TrialUniversity of Colorado, Denver · NCT02767232

via ClinicalTrials.gov

Wikidata facts

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