Also known as BDPLT11, GPIV, GPVI, glycoprotein VI platelet
protein-coding gene in the species Homo sapiens
Gene data
GP6- Name
- glycoprotein VI platelet
- Type
- protein-coding
- Position
- 55,012,055–55,038,264 (−)
- Aliases
- BDPLT11, GPIV, GPVI
- Ensembl
- ENSG00000276065
- RefSeq RNA
- NM_001083899.2, NM_001256017.2, NM_016363.5, XM_054321150.1, XM_054321151.1
- RefSeq protein
- NP_001077368.2, NP_001242946.2, NP_057447.5, XP_054177125.1, XP_054177126.1
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
glycoprotein VI platelet
- Symbol
- GP6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:55,012,055-55,038,264
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI