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thozalinone
Sign in to saveThozalinone (USAN) (brand name Stimsen; former developmental code name CL-39808) is a psychostimulant that has been used as an antidepressant in Europe. It has also been trialed as an anorectic. Thozalinone is described as a "dopaminergic stimulant", and likely acts via inducing the release of dopamine and to a minimal extent norepinephrine; similar to analogue pemoline, it is reportedly devoid of abuse potential unlike most other dopaminergic psychostimulants.
Chemical data
- Formula
- C11H12N2O2
- Molecular weight
- 204.22 g/mol
- IUPAC name
- 2-(dimethylamino)-5-phenyl-1,3-oxazol-4-one
- SMILES
- CN(C)C1=NC(=O)C(O1)C2=CC=CC=C2
- InChIKey
- JJSHYECKYLDYAR-UHFFFAOYSA-N
- XLogP
- 1.5
- Polar surface area
- 41.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 204.09
Show 3 more facts
- chemical formula
- C₁₁H₁₂N₂O₂
- canonical SMILES
- CN(C)C1=NC(=O)C(O1)C2=CC=CC=C2
- Commons category
- Thozalinone
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Synthesis
- Notes
- See also
- References
Thozalinone (USAN) (brand name Stimsen; former developmental code name CL-39808) is a psychostimulant that has been used as an antidepressant in Europe. It has also been trialed as an anorectic. Thozalinone is described as a "dopaminergic stimulant", and likely acts via inducing the release of dopamine and to a minimal extent norepinephrine; similar to analogue pemoline, it is reportedly devoid of abuse potential unlike most other dopaminergic psychostimulants.
==Synthesis== class=skin-invert-image|center|500px|thumb|Synthesis:
Excerpted from Wikipedia’s “thozalinone” article, available under the CC BY-SA 4.0 licence.