Thyreoglobulin

Protein · UniProt

Thyroglobulin

Gene

TG

Organism

Homo sapiens (Human)

Length

2,768 aa

Molecular mass

304,790 Da

Evidence

1: Evidence at protein level

Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:17532758, PubMed:32025030). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030)

• COMPLETED
  Postoperative HyperthyroidismHeidelberg University · NCT01095341
• COMPLETED
  Assessment of Dried Blood Spot Thyroglobulin and Urinary Iodine Concentration in Pregnant WomenSwiss Federal Institute of Technology · NCT03176706
• COMPLETED
  TG Gene Mutations and Congenital HypothyroidismUniversity of Sao Paulo · NCT00493103
• COMPLETED
  Predicting Prognosis and Recurrence of Thyroid Cancer Via New Biomarkers, Urinary Exosomal Thyroglobulin and Galectin-3National Taiwan University Hospital · NCT03488134
• ACTIVE_NOT_RECRUITING
  Diagnostic Accuracy of Fluorodeoxyglucose-18 PET in the Evaluation of RPTC With Patient's Raised Thyroglobulin LevelSuperior University · NCT07062211
• ACTIVE_NOT_RECRUITING
  Urinary Exosomal Biomarkers of Thyroglobulin and Galectin-3 for Prognosis and Follow-up in Patients of Thyroid CancerNational Taiwan University Hospital · NCT04948437

via ClinicalTrials.gov

Wikidata facts

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protein

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