تیروگلوبولین

Also known as uniprot:P01266, TG, thyroglobulin

Thyroglobulin (Tg) is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Tg is secreted and accumulated at hundreds of grams per litre in the extracellular compartment of the thyroid follicles, accounting for approximately half of the protein content of the thyroid gland. Human TG (hTG) is a homodimer of subunits each containing 2768 amino acids as synthesized (a short signal peptide of 19 amino acids may be removed from the N-terminus in the mature protein).

Protein · UniProt

Thyroglobulin

Gene: TG
Organism: Homo sapiens (Human)
Length: 2,768 aa
Molecular mass: 304,790 Da
Evidence: 1: Evidence at protein level

Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:17532758, PubMed:32025030). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030)

3D-structureAlternative splicingCongenital hypothyroidismDirect protein sequencingDisease variantDisulfide bondGlycoproteinHormone

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Swiss-Prot (reviewed) · via UniProt

Clinical Trials

25 registered

COMPLETED
Postoperative HyperthyroidismHeidelberg University · NCT01095341
COMPLETED
Assessment of Dried Blood Spot Thyroglobulin and Urinary Iodine Concentration in Pregnant WomenSwiss Federal Institute of Technology · NCT03176706
COMPLETED
TG Gene Mutations and Congenital HypothyroidismUniversity of Sao Paulo · NCT00493103
COMPLETED
Predicting Prognosis and Recurrence of Thyroid Cancer Via New Biomarkers, Urinary Exosomal Thyroglobulin and Galectin-3National Taiwan University Hospital · NCT03488134
ACTIVE_NOT_RECRUITING
Diagnostic Accuracy of Fluorodeoxyglucose-18 PET in the Evaluation of RPTC With Patient's Raised Thyroglobulin LevelSuperior University · NCT07062211
ACTIVE_NOT_RECRUITING
Urinary Exosomal Biomarkers of Thyroglobulin and Galectin-3 for Prognosis and Follow-up in Patients of Thyroid CancerNational Taiwan University Hospital · NCT04948437

via ClinicalTrials.gov

Wikidata facts

Instance of: protein

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cell component: extracellular space
found in taxon: Homo sapiens
exact match: purl.uniprot.org/uniprot/P01266

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