Tiroglobulina
Sign in to saveAlso known as uniprot:P01266, TG, thyroglobulin
Thyroglobulin (Tg) is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Tg is secreted and accumulated at hundreds of grams per litre in the extracellular compartment of the thyroid follicles, accounting for approximately half of the protein content of the thyroid gland. Human TG (hTG) is a homodimer of subunits each containing 2768 amino acids as synthesized (a short signal peptide of 19 amino acids may be removed from the N-terminus in the mature protein).
Protein · UniProt
Thyroglobulin
- Gene
- TG
- Organism
- Homo sapiens (Human)
- Length
- 2,768 aa
- Molecular mass
- 304,790 Da
- Evidence
- 1: Evidence at protein level
Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:17532758, PubMed:32025030). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030)
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
25 registered- COMPLETEDPostoperative HyperthyroidismHeidelberg University · NCT01095341
- COMPLETEDAssessment of Dried Blood Spot Thyroglobulin and Urinary Iodine Concentration in Pregnant WomenSwiss Federal Institute of Technology · NCT03176706
- COMPLETEDTG Gene Mutations and Congenital HypothyroidismUniversity of Sao Paulo · NCT00493103
- COMPLETEDPredicting Prognosis and Recurrence of Thyroid Cancer Via New Biomarkers, Urinary Exosomal Thyroglobulin and Galectin-3National Taiwan University Hospital · NCT03488134
- ACTIVE_NOT_RECRUITINGDiagnostic Accuracy of Fluorodeoxyglucose-18 PET in the Evaluation of RPTC With Patient's Raised Thyroglobulin LevelSuperior University · NCT07062211
- ACTIVE_NOT_RECRUITINGUrinary Exosomal Biomarkers of Thyroglobulin and Galectin-3 for Prognosis and Follow-up in Patients of Thyroid CancerNational Taiwan University Hospital · NCT04948437
Wikidata facts
- Instance of
- protein
Show 3 more facts
- cell component
- extracellular space
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P01266
via Wikidata · CC0
Article · Español
La tiroglobulina es una proteína que pertenece al grupo de las glicoproteínas y tiene un peso molecular de 660 kDa. Es sintetizada por la tiroides en respuesta a la estimulación de la tirotropina o TSH. El gen que permite su síntesis se encuentra localizado el la especie humana en el cromosoma 8. La tiroglobulina es la molécula precursora de las hormonas tiroideas triyodotironina (T3) y tetrayodotironina o tiroxina (T4). En medicina se suelen medir los niveles de tiroglobulina en la sangre. La elevación de las cifras normales puede tener valor predictivo indicativo de la recidiva de un cáncer de tiroides previamente diagnosticado, por lo que estas hormonas se incluyen dentro del grupo de los marcadores tumorales, aunque su determinación solo es útil en un tipo específico de tumor que se llama carcinoma diferenciado de tiroides.También se emplea la determinación de los anticuerpos antitiroglobulina para el diagnóstico de la tiroiditis de Hashimoto.
Abstract from DBpedia / Wikipedia · CC BY-SA