Thyroid stimulating hormone receptor

Also known as seven transmembrane helix receptor, thyrotropin receptor-I, hTSHR-I, thyrotropin receptor, TSHR, Thyroid-stimulating hormone receptor, TSH receptor, TSH-R

mammalian protein found in Homo sapiens

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Vinony's link graph records 582 inbound references to Thyroid stimulating hormone receptor, and connects out to PubMed, Ensembl genome database project and Wikidata.

It is catalogued under topics including Genes on human chromosome 14, G protein-coupled receptors and Thyroid.

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Protein · UniProt

Thyrotropin receptor

Gene: TSHR
Organism: Homo sapiens (Human)
Length: 764 aa
Molecular mass: 86,844 Da
Evidence: 1: Evidence at protein level

Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase (PubMed:11847099, PubMed:35940205, PubMed:35940204). This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid…

3D-structureAlternative splicingCell membraneCongenital hypothyroidismDirect protein sequencingDisease variantDisulfide bondG protein-coupled receptor

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Swiss-Prot (reviewed) · via UniProt