Structure via PubChem · Public domain (PubChem)
تیلیسولول
Sign in to saveTilisolol (INN, trade name Selecal) is a beta blocker.
Chemical data
- Formula
- C17H24N2O3
- Molecular weight
- 304.4 g/mol
- IUPAC name
- 4-[3-(tert-butylamino)-2-hydroxypropoxy]-2-methylisoquinolin-1-one
- SMILES
- CC(C)(C)NCC(COC1=CN(C(=O)C2=CC=CC=C21)C)O
- InChIKey
- TWVUMMQUXMYOOH-UHFFFAOYSA-N
- XLogP
- 1.1
- Polar surface area
- 61.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
30 papers- Biodistribution and pharmacokinetics of O-palmitoyl tilisolol, a lipophilic prodrug of tilisolol, after intravenous administration in rats.Biological & pharmaceutical bulletin · 2002
- Characterization of ocular pharmacokinetics of tilisolol after instillation into anesthetized rabbits.Biological & pharmaceutical bulletin · 1999
- Tilisolol hydrochloride dilates coronary arteries through an ATP-sensitive K(+)-channel opening mechanism in dogs.Cardiovascular drugs and therapy · 1996
- Transport of timolol and tilisolol in rabbit corneal epithelium.Biological & pharmaceutical bulletin · 2006
- In situ ocular absorption of tilisolol through ocular membranes in albino rabbits.Journal of pharmaceutical sciences · 1996
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 304.179
Show 3 more facts
- canonical SMILES
- CC(C)(C)NCC(COC1=CN(C(=O)C2=CC=CC=C21)C)O
- chemical formula
- C₁₇H₂₄N₂O₃
- subject has role
- antiarrhythmic agent
Sources (2)
via Wikidata · CC0