tiratricol
Sign in to saveAlso known as 3,3',5-triiodothyroacetic acid, TRIAC, Triacana, Tiratricolum, Triiodothyroacetic acid, 3',3,5-Triiodothyroacetic acid
Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue. Triiodothyroacetic acid is also a physiologic thyroid hormone that is present in the normal organism in low concentrations. Tiratricol is an analogue of a naturally circulating metabolite of the active thyroid hormone T3. MCT8 is a specific thyroid hormone transporter. While T3 and T4 thyroid hormones rely on MCT8 to enter several tissues such as the brain, tiratricol can enter cells independently of MCT8. Once inside cells, tiratricol activates the thyroid hormone receptor in a similar way to endogenous
Key facts
- Drug.O
- 4
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 470610738
- Drug.image
- Tiratricol.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 240
- Drug.image2
- Tiratricol 3D ball.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model of the tiratricol molecule
- Drug.class
- Thyroid hormone
- Drug.ATC_prefix
- H03
- Drug.ATC_suffix
- AA04
- Drug.legal_EU
- Rx-only
- Drug.metabolism
- Liver glucuronidation
- Drug.excretion
- Bile duct
- Drug.CAS_number
- 51-24-1
- Drug.PubChem
- 5803
- Drug.IUPHAR_ligand
- 2637
via Wikipedia infobox
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 621.763
Show 4 more facts
- chemical formula
- C₁₄H₉I₃O₄
- canonical SMILES
- C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(=O)O)I)I)O
- medical condition treated
- thyroid cancer
- Commons category
- Tiratricol
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Medical uses
- Society and culture
- Legal status
- Research
- References
Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue. Triiodothyroacetic acid is also a physiologic thyroid hormone that is present in the normal organism in low concentrations. Tiratricol is an analogue of a naturally circulating metabolite of the active thyroid hormone T3. MCT8 is a specific thyroid hormone transporter. While T3 and T4 thyroid hormones rely on MCT8 to enter several tissues such as the brain, tiratricol can enter cells independently of MCT8. Once inside cells, tiratricol activates the thyroid hormone receptor in a similar way to endogenous T3.
The most common side effects are excessive sweating, irritability, anxiety and nightmares.
Excerpted from Wikipedia’s “tiratricol” article, available under the CC BY-SA 4.0 licence.