TNFRSF10A
Sign in to saveAlso known as APO2, CD261, DR4, TRAILR-1, TRAILR1, tumor necrosis factor receptor superfamily member 10a, TNF receptor superfamily member 10a
protein-coding gene in the species Homo sapiens
Gene data
TNFRSF10A- Name
- TNF receptor superfamily member 10a
- Type
- protein-coding
- Position
- 23,183,123–23,225,145 (−)
- Aliases
- APO2, CD261, DR4, TRAILR-1, TRAILR1
- Ensembl
- ENSG00000104689
- RefSeq RNA
- NM_003844.4
- RefSeq protein
- NP_003835.3
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
apoptotic processsignal transductionsignal transductionactivation of NF-kappaB-inducing kinase activityextrinsic apoptotic signaling pathway via death domain receptorsextrinsic apoptotic signaling pathway via death domain receptorsTRAIL-activated apoptotic signaling pathwayTRAIL-activated apoptotic signaling pathway
Molecular function
Pathways
Cytokine-cytokine receptor interaction - Homo sapiens (human)Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)p53 signaling pathway - Homo sapiens (human)Apoptosis - Homo sapiens (human)Necroptosis - Homo sapiens (human)Natural killer cell mediated cytotoxicity - Homo sapiens (human)Pathogenic Escherichia coli infection - Homo sapiens (human)Salmonella infection - Homo sapiens (human)Influenza A - Homo sapiens (human)Lipid and atherosclerosis - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
TNF receptor superfamily member 10a
- Symbol
- TNFRSF10A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:23,183,123-23,225,145
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI