TNNC1
Sign in to saveAlso known as CMH13, CMD1Z, TN-C, TNC, TNNC, Troponin C type 1, troponin C1, slow skeletal and cardiac type
protein-coding gene in the species Homo sapiens
Gene data
TNNC1- Name
- troponin C1, slow skeletal and cardiac type
- Type
- protein-coding
- Position
- 52,451,082–52,454,071 (−)
- Aliases
- CMD1Z, CMH13, TN-C, TNC, TNNC
- Ensembl
- ENSG00000114854
- RefSeq RNA
- NM_003280.3
- RefSeq protein
- NP_003271.1
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
troponin C1, slow skeletal and cardiac type
- Symbol
- TNNC1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:52,451,082-52,454,071
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TNNC1 PDB 1aj4.png
Show 8 more facts
- HomoloGene ID
- 55728
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7134
- genomic end
- 52454041
- genomic start
- 52451100
- chromosome
- human chromosome 3
- cytogenetic location
- 3p21.1
- Commons category
- Troponin C type 1
Sources (4)
via Wikidata · CC0