TNNC1

Also known as CMH13, CMD1Z, TN-C, TNC, TNNC, Troponin C type 1, troponin C1, slow skeletal and cardiac type

protein-coding gene in the species Homo sapiens

Gene data

TNNC1

Name: troponin C1, slow skeletal and cardiac type
Type: protein-coding
Position: 52,451,100–52,454,041 (−)
Aliases: CMD1Z, CMH13, TN-C, TNC, TNNC
Ensembl: ENSG00000114854
RefSeq RNA: NM_003280.3
RefSeq protein: NP_003271.1

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008].