tranylcypromine
Sign in to saveAlso known as trans-2-phenylcyclopropylamine, (1R*,2S*)-2-phenylcyclopropan-1-amine, (±)-trans-2-phenylcyclopropylamine, DL-tranylcypromine, trans-DL-2-phenylcyclopropylamine, transamine, racemic tranylcypromine, rac-tranylcypromine
Tranylcypromine, sold under the brand name Parnate among others, is a monoamine oxidase inhibitor (MAOI). More specifically, tranylcypromine acts as nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO). It is used as an antidepressant and anxiolytic agent in the clinical treatment of mood and anxiety disorders, respectively. It is also effective in the treatment of ADHD.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 402690453
- Drug.image
- Racemic-Tranylcypromine-2D-Skeletal.png
- Drug.image_class
- skin-invert-image
- Drug.width
- 375
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250px
- Drug.imageL
- (+)-Tranylcypromine 3D-Ball-and-Stick.png
- Drug.widthL
- 210
- Drug.imageR
- (-)-Tranylcypromine 3D-Ball-and-Stick.png
- Drug.widthR
- 210
- Drug.caption2
- (1R,2S)-(+)-tranylcypromine (left),(1S,2R)-(−)-tranylcypromine (right)
- Drug.tradename
- Parnate, many generics
- Drug.MedlinePlus
- a682088
- Drug.DailyMedID
- Tranylcypromine
- Drug.pregnancy_AU
- B2
- Drug.legal_AU
- S4
via Wikipedia infobox
Chemical data
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
2,365 papers- Tranylcypromine-derived LSD1 inhibitors: Synthetic strategies, structure-activity relationships, and anticancer potential.European journal of medicinal chemistry · 2025
- Tranylcypromine: a review.Clinical pharmacology and therapeutics · 1965
- Tranylcypromine.Lancet (London, England) · 1963
- Efficacy of Tranylcypromine in Bipolar Depression: A Systematic Review.Journal of clinical psychopharmacology · 2015
- Tranylcypromine: new perspectives on an "old" drug.European archives of psychiatry and clinical neuroscience · 2006
via PubMed
Wikidata facts
Show 7 more facts
- World Health Organisation international non-proprietary name
- транилципромин
- Commons category
- Tranylcypromine
- defined daily dose
- 10
- significant drug interaction
- procarbazine
- medical condition treated
- post-traumatic stress disorder
- subject has role
- anxiolytic
- legal status (medicine)
- boxed warning
via Wikidata · CC0
~10 min read
Encyclopedic overview
15 sectionsContents
- Medical uses
- Contraindications
- Dietary restrictions
- Adverse effects
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Synthesis
- Analogues
- History
- Research
- See also
- References
Tranylcypromine, sold under the brand name Parnate among others, is a monoamine oxidase inhibitor (MAOI). More specifically, tranylcypromine acts as nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO). It is used as an antidepressant and anxiolytic agent in the clinical treatment of mood and anxiety disorders, respectively. It is also effective in the treatment of ADHD.
Tranylcypromine is also known as trans-2-phenylcyclopropyl-1-amine and is formed pro forma from the cyclization of amphetamine's isopropylamine side chain. As a result, it is classified structurally as a substituted phenethylamine and amphetamine, or more specifically as a phenylcyclopropylamine.
Excerpted from Wikipedia’s “tranylcypromine” article, available under the CC BY-SA 4.0 licence.