تریپرولیدین

Also known as Actidil®, (E)-2-[3-(1-pyrrolidinyl)-1-p-toluenepropenyl]pyridine, trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene, trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene, Triprolidin, Triprolidine, Tripolidina, Triprolidinum

Triprolidine is an over-the-counter antihistamine with anticholinergic properties. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. As with many antihistamines, the most common side effect is drowsiness.

Chemical data

Formula: C19H22N2
Molecular weight: 278.4 g/mol
IUPAC name: 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
SMILES: CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3
InChIKey: CBEQULMOCCWAQT-WOJGMQOQSA-N
XLogP: 3.9
Polar surface area: 16.1 Å²
H-bond donors: 0
H-bond acceptors: 2
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1982
Admin. routes: oral
Indications: allergic disease

via ChEMBL · EBI

Research

420 papers

Triprolidine.2006
Triprolidine.2012
Efficacy of Triprolidine in the Treatment of Temporary Sleep Disturbance.Journal of clinical pharmacology · 2021
Bioavailability of Triprolidine as a Single Agent or in Combination With Pseudoephedrine: A Randomized, Open-Label Crossover Study in Healthy Volunteers.Clinical pharmacology in drug development · 2020
Triprolidine: 104-week feeding study in rats.Fundamental and applied toxicology : official journal of the Society of Toxicology · 1995

via PubMed

Wikidata facts

Mass: 278.178299
Has use: medication

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chemical formula: C₁₉H₂₂N₂
canonical SMILES: CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3
isomeric SMILES: CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3
World Health Organisation international non-proprietary name: triprolidine
defined daily dose: 7.5
physically interacts with: Histamine receptor H1
Commons category: Triprolidine

Sources (4)

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