Structure via PubChem · Public domain (PubChem)
Triprolidina
Sign in to saveAlso known as Actidil®, (E)-2-[3-(1-pyrrolidinyl)-1-p-toluenepropenyl]pyridine, trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene, trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene, Triprolidin, Triprolidine, Tripolidina, Triprolidinum
composto chimico
Chemical data
- Formula
- C19H22N2
- Molecular weight
- 278.4 g/mol
- IUPAC name
- 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
- SMILES
- CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3
- InChIKey
- CBEQULMOCCWAQT-WOJGMQOQSA-N
- XLogP
- 3.9
- Polar surface area
- 16.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- oral
- Indications
- allergic disease
via ChEMBL · EBI
Research
420 papers- Triprolidine.2006
- Triprolidine.2012
- Efficacy of Triprolidine in the Treatment of Temporary Sleep Disturbance.Journal of clinical pharmacology · 2021
- Bioavailability of Triprolidine as a Single Agent or in Combination With Pseudoephedrine: A Randomized, Open-Label Crossover Study in Healthy Volunteers.Clinical pharmacology in drug development · 2020
- Triprolidine: 104-week feeding study in rats.Fundamental and applied toxicology : official journal of the Society of Toxicology · 1995
via PubMed
Wikidata facts
- Mass
- 278.178299
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₉H₂₂N₂
- canonical SMILES
- CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3
- isomeric SMILES
- CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3
- World Health Organisation international non-proprietary name
- triprolidine
- defined daily dose
- 7.5
- physically interacts with
- Histamine receptor H1
- Commons category
- Triprolidine
via Wikidata · CC0
Article · Italiano
La triprolidina è un farmaco antistaminico anti H1 di prima generazione con proprietà anticolinergiche, viene utilizzato per contrastare i sintomi di raffreddore, allergia, reazioni asmatiche ed orticaria. Spesso è associato a principi attivi con proprietà simpaticomimetiche (pseudoefedrina) o analgesiche come il paracetamolo. Come la maggior parte degli anti H1 la triprolidina può dare sonnolenza.
Abstract from DBpedia / Wikipedia · CC BY-SA