tritoqualine

Also known as inhibostamin, hypostamine, hypostamin, tritoqualin

Tritoqualine, also known as hypostamine, is an inhibitor of the enzyme histidine decarboxylase and therefore an atypical antihistamine, used for the treatment of urticaria and allergic rhinitis with no known adverse effects.

Chemical data

Formula: C26H32N2O8
Molecular weight: 500.5 g/mol
IUPAC name: 7-amino-4,5,6-triethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one
SMILES: CCOC1=C(C(=C(C2=C1C(OC2=O)C3C4=C(C5=C(C=C4CCN3C)OCO5)OC)N)OCC)OCC
InChIKey: IRGJVQIJENCTQF-UHFFFAOYSA-N
XLogP: 3.7
Polar surface area: 111 Å²
H-bond donors: 1
H-bond acceptors: 10
Formal charge: 0

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Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
Indications: allergic disease

via ChEMBL · EBI

Research

43 papers

[Hypostamine (tritoqualine), a synthetic reference antihistaminic].Allergie et immunologie · 1988
Inhibitory effect of tritoqualine (TRQ) on histamine release from mast cells.Japanese journal of pharmacology · 1985
Tritoqualine and some aspects of histamine metabolism.Arzneimittel-Forschung · 1986
Clinical pharmacology of tritoqualine: a comparative study against dexchlorpheniramine in allergic rhinitis.International journal of clinical pharmacology research · 1986
[Effect of tritoqualine on the histamine levels of whole blood].Annales francaises d'anesthesie et de reanimation · 1985

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Wikidata facts

Subclass of: chemical compound
Mass: 500.216

Show 3 more facts

chemical formula: C₂₆H₃₂N₂O₈
canonical SMILES: CCOC1=C(C(=C(C2=C1C(OC2=O)C3C4=C(C5=C(C=C4CCN3C)OCO5)OC)N)OCC)OCC
subject has role: H1 antagonist

Sources (2)

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Encyclopedic overview

1 sections

Contents

References

== References ==

Excerpted from Wikipedia’s “tritoqualine” article, available under the CC BY-SA 4.0 licence.

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